Blythe is a passionate chamber musician and has had the honor of collaborating with many artists including Menahem Pressler, Yuja Wang, Lisa Batiashvili, Renaud Capuçon, Leonidas Kavakos, Gábor Takács-Nagy, Kim Kashkashian, Lawrence Power, Nobuko Imai, Gautier Capuçon, Gary Hoffman and the Quatuor Ebène. She is currently a member of the Serafino Quartet.
She has performed in numerous festivals, such as the Miyazaki Festival in Japan, Schloss Elmau and Cappenberg in Germany, and Bellerive and Verbier Festivals in Switzerland.
She was instrumental in creating the Verbier Festival Chamber Orchestra and works closely with the orchestra’s music director, Gábor Takács-Nagy. The Chamber Orchestra tours internationally with such prominent artists as Martha Argerich, Joshua Bell and Martin Fröst, and made its first recording with Maxim Vengerov for EMI. She has been the Chamber Orchestra’s concertmaster, and currently leads the viola section.